The amazing Spug recommended I take a look at Mollio. Its an open source CSS/JS framework for web sites.

And unlike most of the other frameworks I've tried - this one works. And works well.

It took me less than 30 minutes to apply it a Notes database, and now I have full domino-content production, and a very nice web interface to boot. Well recommended. (updated to correctly spell the product name.. D'oh!)